Interaction network and enrichment analysis of genes downregulated in obesity
Canned Analysis
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General Information
AccessionDCA00033367
TitleInteraction network and enrichment analysis of genes downregulated in obesity
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by obesity and healthy control cells in the Adipose tissue cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rpl13a|Rpl12|Ccl21b|Acta1|Cd74|Tuba1a|Rps15a|Cyp2e1|Clu|Ccl21a|Rps7|H2-Eb1|Cd52|Tbc1d10c|Rpl7|Tmsb10|Dgat2|Gm5528|Rps14|Rpl5|Rps19|Rps5|Cnbp|Rps3a1|Lyz2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:319
Cell TypeAdipose tissue
DO IDDOID:9970
Disease Nameobesity
Organismmouse
UMLS CUIC0028754
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM105992, GSM105993, GSM105994
Perturbed SamplesGSM105989, GSM105990, GSM105991
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE4692
Gene Expression Omnibus
High and low weight gainers: adipose tissue
7
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