Interaction network and enrichment analysis of genes downregulated in type 2 diabetes mellitus
Canned Analysis
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General Information
AccessionDCA00033369
TitleInteraction network and enrichment analysis of genes downregulated in type 2 diabetes mellitus
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by type 2 diabetes mellitus and healthy control cells in the Renal Tissue cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Acy3|Cyp2e1|Ybx1|Inmt|Tmem176a|Napsa|Rpl34|Keg1|Tcn2|Gyk|Gatm|Miox|Hsd3b2|Cyp4b1|Hsd3b4|Sod1|Rpl41|Hist2h3c1|Txn1|Rpl28|Tmem176b|Pdzk1ip1|Atp11a|Ly6a|Cndp2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:320
Cell TypeRenal Tissue
DO IDDOID:9352
Disease Nametype 2 diabetes mellitus
Organismmouse
UMLS CUIC0011860
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM9920, GSM9921, GSM9922, GSM9923, GSM9924, GSM9925
Perturbed SamplesGSM9926, GSM9927, GSM9928, GSM9929, GSM9930, GSM9931
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE642
Gene Expression Omnibus
Type 2 diabetes and renal function
7
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