Interaction network and enrichment analysis of genes downregulated in Senescence
Canned Analysis
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General Information
AccessionDCA00033401
TitleInteraction network and enrichment analysis of genes downregulated in Senescence
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Senescence and healthy control cells in the CNS - Brain - Hippocampus (MMHCC) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Gm16409|Ybx1|Nudt3|Rnf10|Gm10845|Plk3|Tmsb10|Hsph1|Polr2m|Ndufa7|Pdha1|Syt11|Hmgn1|Bsg|Prkar1b|Ldha|Nrep|Gm19558|Ubb|Rgs14|Mfge8|Mtch2|Tubb3|Calm3|Cnih2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:331
Cell TypeCNS - Brain - Hippocampus (MMHCC)
Disease NameSenescence
Organismmouse
UMLS CUIC0001792
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM114426, GSM114427, GSM114428, GSM114430, GSM114431, GSM114433, GSM114434, GSM114436, GSM114437
Perturbed SamplesGSM114391, GSM114393, GSM114394, GSM114396, GSM114397, GSM114400, GSM114402, GSM114409, GSM114410, GSM114412, GSM114414, GSM114417, GSM114424, GSM114425
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5078
Gene Expression Omnibus
Age effect on the hippocampus
7
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