Interaction network and enrichment analysis of genes upregulated in Escherichia coli infection of the central nervous system
Canned Analysis
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General Information
AccessionDCA00033414
TitleInteraction network and enrichment analysis of genes upregulated in Escherichia coli infection of the central nervous system
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Escherichia coli infection of the central nervous system and healthy control cells in the CNS - Brain (MMHCC) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Mt2|Rhob|Lcn2|Sgk1|Ly6a|Ifitm3|Akap12|Tgtp2|Rps12|AW112010|E430024C06Rik|1200016E24Rik|Gbp2b|Sepp1|Mt1|Nfkbia|Gm19439|Pcsk1n|Pnp|Rpl32|Sepw1|Mt3|Htra1|LOC100503721|BC094435
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:341
Cell TypeCNS - Brain (MMHCC)
Disease NameEscherichia coli infection of the central nervous system
Organismmouse
UMLS CUIC1320188
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM73001, GSM73002, GSM73014, GSM73015, GSM73016, GSM73017
Perturbed SamplesGSM72507, GSM73000, GSM73018, GSM73019, GSM73340, GSM73341
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE3253
Gene Expression Omnibus
Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior
7
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