Interaction network and enrichment analysis of genes downregulated in skin squamous cell carcinoma
Canned Analysis
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General Information
AccessionDCA00033439
TitleInteraction network and enrichment analysis of genes downregulated in skin squamous cell carcinoma
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by skin squamous cell carcinoma and healthy control cells in the Normal skin and squamous cell carcinoma (SCC) tumor biopsies cell type.
Analysis URLhttp://genemania.org/#/search/human/KRT2|LOR|RPL34|RPS9|RPL30|RPL7A|RPS23|RPS27|HOPX|RPL9|RPL23A|RPS18|RPLP1|RPL3|RPL12|FADS2|LGALS3|FABP4|RPS4X|RPL32|RPSA|PIP|RPS20|GLTSCR2|ATP5A1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:627
Cell TypeNormal skin and squamous cell carcinoma (SCC) tumor biopsies
DO IDDOID:3151
Disease Nameskin squamous cell carcinoma
Organismhuman
UMLS CUIC0553723
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM47616, GSM47617, GSM47618, GSM47619, GSM47620, GSM47621
Perturbed SamplesGSM47622, GSM47623, GSM47624, GSM47625, GSM47626
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE2503
Gene Expression Omnibus
Non-melanoma skin cancer
19
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