Interaction network and enrichment analysis of genes downregulated in Cardiac Hypertrophy
Canned Analysis
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General Information
AccessionDCA00033445
TitleInteraction network and enrichment analysis of genes downregulated in Cardiac Hypertrophy
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Cardiac Hypertrophy and healthy control cells in the cardiomyocyte cell type.
Analysis URLhttp://genemania.org/#/search/rat/Actb|Myh7|Col3a1|Actc1|Gapdh|Actg1|Vcl|Eef2|Mmp14|COX2|Arf1|Pabpc4|Postn|Nedd4|Cyc1|Col1a1|Dsp|Mb|Col6a2|Tmed2|Acta2|Tpm4|Itgb1|Igfbp7|Ctsd
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:354
Cell Typecardiomyocyte
Disease NameCardiac Hypertrophy
Organismrat
UMLS CUIC1383860
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM17077, GSM17078
Perturbed SamplesGSM17079, GSM17080
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1055
Gene Expression Omnibus
Cardiac myocyte hypertrophy induced by fibronectin
7
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