Interaction network and enrichment analysis of genes downregulated in Spinal Cord Injury
Canned Analysis
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General Information
AccessionDCA00033575
TitleInteraction network and enrichment analysis of genes downregulated in Spinal Cord Injury
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Spinal Cord Injury and healthy control cells in the CNS - Spinal Cord (MMHCC) cell type.
Analysis URLhttp://genemania.org/#/search/rat/ND3|Reg3b|Fth1|Tpt1|Hspa8|Rpl13a|Atp5j2|Pcp4|Ppp1cc|Rps23|Mdh1|Pfkp|Nefl|Hspb1|Uqcrb|LOC689064|Plp1|Bex1|Tubb2b|Nptx1|Chgb|LOC100360413|Uqcrh|Ubc|Rpl31
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:427
Cell TypeCNS - Spinal Cord (MMHCC)
Disease NameSpinal Cord Injury
Organismrat
UMLS CUIC0037929
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM418673, GSM418674, GSM418675, GSM418676, GSM418677, GSM418678, GSM418679, GSM418680, GSM418681, GSM418682, GSM418683
Perturbed SamplesGSM418657, GSM418658, GSM418659, GSM418660, GSM418661, GSM418662, GSM418663, GSM418664, GSM418665, GSM418666, GSM418667, GSM418668, GSM418669, GSM418670, GSM418671, GSM418672
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE16710
Gene Expression Omnibus
Expression data from adult rat tail MNs after spinal cord transection
7
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