Interaction network and enrichment analysis of genes downregulated in breast cancer
Canned Analysis
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General Information
AccessionDCA00033615
TitleInteraction network and enrichment analysis of genes downregulated in breast cancer
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by breast cancer and healthy control cells in the Breast Epithelium cell type.
Analysis URLhttp://genemania.org/#/search/human/IER2|ATF3|IER3|FOSB|EGR1|RGS2|PABPC1|H3F3B|ANXA1|TUBA1A|CXCL2|RPL30|B2M|TSC22D1|FOS|TRIB1|RPL4|RPL12|LALBA|UBC|TPT1|PPA1|RPL13A|ARHGAP29|RPS10
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortimkenny92
CREEDS IDdz:448
Cell TypeBreast Epithelium
DO IDDOID:1612
Disease Namebreast cancer
Organismhuman
UMLS CUIC1458155
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM241999, GSM242000, GSM242001, GSM242002, GSM242003, GSM242004, GSM242005, GSM242006, GSM242007, GSM242008, GSM242009, GSM242010, GSM242011, GSM242012, GSM242013
Perturbed SamplesGSM242014, GSM242015, GSM242016, GSM242017, GSM242018, GSM242019, GSM242020, GSM242021, GSM242022, GSM242023, GSM242024, GSM242025, GSM242026, GSM242027
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE9574
Gene Expression Omnibus
Breast cancer: histologically normal breast epithelium
7
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