Interaction network and enrichment analysis of genes downregulated following Nitric oxide treatment
Canned Analysis
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General Information
AccessionDCA00033619
TitleInteraction network and enrichment analysis of genes downregulated following Nitric oxide treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Nitric oxide treated cells and untreated control cells in the CD3+ T cell cell type.
Analysis URLhttp://genemania.org/#/search/human/HNRNPA1P10|CLC|GIMAP6|GIMAP7|IFITM1|GPR171|HSPA8|CMPK2|GBP5|CCR7|H3F3AP4|PSMB9|NELL2|ITK|IFITM3|SELL|TUBA1A|TMEM123|NMI|NFKBIA|GBP1|DTX3L|ISG20|IARS|GIMAP4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3181
Cell TypeCD3+ T cell
Drug NameNitric oxide
DrugBank IDDB00435
Organismhuman
PubChem CID145068
SMILES ID[N]=O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM349729, GSM349730, GSM349734, GSM349739
Perturbed SamplesGSM349725, GSM349731, GSM349736, GSM349740
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE13887
Gene Expression Omnibus
Systemic lupus erythematosus CD3+ T cells
14
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