Interaction network and enrichment analysis of genes upregulated in Niemann-Pick disease
Canned Analysis
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General Information
AccessionDCA00033700
TitleInteraction network and enrichment analysis of genes upregulated in Niemann-Pick disease
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Niemann-Pick disease and healthy control cells in the brain tissue cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ctsd|Ctss|C1qa|Gfap|Apoe|B2m|Lyz2|Mt2|Mpeg1|C4b|Neurod1|Tyrobp|Ttr|Hexb|C1qc|Ftl2|Erdr1|Vim|Sepp1|Grn|Aldoc|Ifitm3|Ftl1|Nrep|Appl2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdz:469
Cell Typebrain tissue
DO IDDOID:14504
Disease NameNiemann-Pick disease
Organismmouse
UMLS CUIC0220756
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM973238, GSM973239, GSM973240, GSM973241, GSM973244, GSM973245, GSM973248, GSM973249, GSM973252, GSM973253, GSM973254, GSM973255, GSM973258, GSM973259, GSM973261, GSM973262
Perturbed SamplesGSM973242, GSM973243, GSM973246, GSM973247, GSM973250, GSM973251, GSM973256, GSM973257, GSM973260, GSM973263, GSM973264
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE39621
Gene Expression Omnibus
Niemann-Pick Type C disease spleen: time course
7
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