Interaction network and enrichment analysis of genes downregulated in pancreatic cancer
Canned Analysis
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General Information
AccessionDCA00033709
TitleInteraction network and enrichment analysis of genes downregulated in pancreatic cancer
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by pancreatic cancer and healthy control cells in the Pancreatic tissue cell type.
Analysis URLhttp://genemania.org/#/search/human/INS|REG1A|REG1B|MT2A|CPA2|PRSS3|RGS2|C7|PRSS3P2|DEFA5|PLA2G1B|MT1HL1|IGHA2|CEL|SSR4|MT1X|ND2|MT1E|PRDX4|OAT|SI|CUZD1|DEFA6|RPL21|SGK1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdz:475
Cell TypePancreatic tissue
DO IDDOID:1793
Disease Namepancreatic cancer
Organismhuman
UMLS CUIC0153463
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM414928, GSM414930, GSM414932, GSM414934, GSM414938, GSM414940, GSM414942, GSM414947, GSM414953, GSM414955, GSM414957, GSM414963, GSM414966, GSM414970, GSM414972, GSM414975
Perturbed SamplesGSM414924, GSM414925, GSM414926, GSM414927, GSM414929, GSM414931, GSM414933, GSM414935, GSM414936, GSM414937, GSM414939, GSM414941, GSM414943, GSM414944, GSM414945, GSM414946, GSM414948, GSM414949, GSM414950, GSM414951, GSM414952, GSM414954, GSM414956, GS
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE16515
Gene Expression Omnibus
Pancreatic Tumor and Normal tissue samples
7
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