Interaction network and enrichment analysis of genes downregulated in prostate cancer
Canned Analysis
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General Information
AccessionDCA00033731
TitleInteraction network and enrichment analysis of genes downregulated in prostate cancer
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by prostate cancer and healthy control cells in the LNCaP cell type.
Analysis URLhttp://genemania.org/#/search/human/TUBA1C|LDHA|H2AFZ|GAGE8|GAGE12F|GAPDH|GAGE12D|ODC1|NME1|PTMA|LOC728026|PRDX1|PTTG1|GAGE3|RPSA|TUBB|PKM|HMGN1|CKS2|PHGDH|ATP5B|UBE2S|HMGN2|CWC15|NDUFAB1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:485
Cell TypeLNCaP
DO IDDOID:10283
Disease Nameprostate cancer
Organismhuman
UMLS CUIC0376358
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM969458, GSM969460, GSM969462
Perturbed SamplesGSM969459, GSM969461, GSM969463
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE39452
Gene Expression Omnibus
Expression data of EZH2-dependent genes in prostate cancer cell lines
12
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