Interaction network and enrichment analysis of genes downregulated in GATA4 Deletion - for the second exon
Canned Analysis
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General Information
AccessionDCA00033759
TitleInteraction network and enrichment analysis of genes downregulated in GATA4 Deletion - for the second exon
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between GATA4 Deletion - for the second exon cells and control cells in the Heart ventricles (of GATA4 animals heterozygous) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Fhl2|Pdk4|Cox4i1|Tuba4a|Eno3|Tnnc1|Tnnt2|Cox8b|Ptgds|LOC100505088|Eef1a2|Atp5d|Ndufb11|Gm3244|Ndufb10|Csrp3|Ech1|Mybpc3|Acadvl|Rplp0|Ndufa8|Obscn|Hba-a2|Rps23|Rplp2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:739
Cell TypeHeart ventricles (of GATA4 animals heterozygous)
Gene Symbol (human)GATA4
Gene Symbol (mouse)Gata4
Organismmouse
Perturbation TypeDeletion - for the second exon
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM126895, GSM126898, GSM126901, GSM126902
Perturbed SamplesGSM126909, GSM126910, GSM126911, GSM126912, GSM126913
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5500
Gene Expression Omnibus
Gata4 heterozygous mutant heart response to pressure overload
14
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