Interaction network and enrichment analysis of genes downregulated in atopic dermatitis
Canned Analysis
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General Information
AccessionDCA00033781
TitleInteraction network and enrichment analysis of genes downregulated in atopic dermatitis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by atopic dermatitis and healthy control cells in the derma (skin) cell type.
Analysis URLhttp://genemania.org/#/search/human/LOR|FLG|FLG2|HBA2|ND2|RPL9|KRT77|TMEM45A|RPL34|RPS26|KRTDAP|SBSN|KRT1|COX1|UBC|LCE2B|KRT10|SFRP2|DEGS1|SNHG5|DCAF6|RPL30|H3F3B|CREG1|RPS18
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorvcogliani
CREEDS IDdz:509
Cell Typederma (skin)
DO IDDOID:3310
Disease Nameatopic dermatitis
Organismhuman
UMLS CUIC0011615
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM815451, GSM815452, GSM815453, GSM815454, GSM815455, GSM815456, GSM815457, GSM815458
Perturbed SamplesGSM815426, GSM815428, GSM815430, GSM815432, GSM815434, GSM815436, GSM815439, GSM815441, GSM815443, GSM815445, GSM815447, GSM815449
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE32924
Gene Expression Omnibus
Nonlesional atopic dermatitis skin
14
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