Interaction network and enrichment analysis of genes downregulated in Alzheimer's disease
Canned Analysis
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General Information
AccessionDCA00033811
TitleInteraction network and enrichment analysis of genes downregulated in Alzheimer's disease
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Alzheimer's disease and healthy control cells in the male frontal cortex cell type.
Analysis URLhttp://genemania.org/#/search/human/TSPAN7|HSPA8|GDI1|RNU2-2P|MAL2|CAMK2N1|OAZ1|HIST1H4C|SEPT3|SNORD116-15|RPL5|ATP1A3|SNCA|RPL13AP5|YWHAE|GAPDH|MGST3|FAM171B|SPARC|ARL6IP1|ATP6V1G2-DDX39B|VAMP2|RN7SK|GNB1|LUZP6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatornbongio
CREEDS IDdz:523
Cell Typemale frontal cortex
DO IDDOID:10652
Disease NameAlzheimer's disease
Organismhuman
UMLS CUIC0002395
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM907807, GSM907813, GSM907814, GSM907816, GSM907818, GSM907819, GSM907820, GSM907822, GSM907823
Perturbed SamplesGSM907792, GSM907795, GSM907801, GSM907802, GSM907804, GSM907805, GSM907806
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE36980
Gene Expression Omnibus
Postmortem Alzheimer's disease brains: Hisayama study
42
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