Interaction network and enrichment analysis of genes downregulated in facioscapulohumeral muscular dystrophy
Canned Analysis
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General Information
AccessionDCA00033837
TitleInteraction network and enrichment analysis of genes downregulated in facioscapulohumeral muscular dystrophy
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by facioscapulohumeral muscular dystrophy and healthy control cells in the skeletal muscle (biceps & deltoid) cell type.
Analysis URLhttp://genemania.org/#/search/human/LDHA|C8orf22|LOC285556|SGK1|SLN|PLN|DCAF6|CSRP3|COX7A1|MYH2|RPS20|COX2|TNNC2|COX6C|MYLPF|PHYH|LOC653513|PGAM2|TNNI1|ACTN3|MYL1|NDUFA1|SMPX|ACTA1|CKM
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:541
Cell Typeskeletal muscle (biceps & deltoid)
DO IDDOID:11727
Disease Namefacioscapulohumeral muscular dystrophy
Organismhuman
UMLS CUIC0238288
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM377458, GSM377461, GSM377464, GSM377467, GSM377470
Perturbed SamplesGSM377457, GSM377460, GSM377463, GSM377466, GSM377469
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE15090
Gene Expression Omnibus
Gene expression profiles in muscle tissue from FSHD patients
14
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