Interaction network and enrichment analysis of genes upregulated in monoclonal gammopathy of uncertain significance
Canned Analysis
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General Information
AccessionDCA00033866
TitleInteraction network and enrichment analysis of genes upregulated in monoclonal gammopathy of uncertain significance
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by monoclonal gammopathy of uncertain significance and healthy control cells in the Bone marrow plasma cells cell type.
Analysis URLhttp://genemania.org/#/search/human/S100A8|ACTG1|RPS28|PELI1|B2M|NAMPT|MCL1|EZR|RPS17|S100A10|RNA18S5|RPL17|SLC2A3|DEFA1B|RPL9|HSPA5|DAD1|EIF1|HLA-G|HLA-B|RPL41P5|HLA-A|RPS27|LYZ|LOC100130331
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:563
Cell TypeBone marrow plasma cells
DO IDDOID:7442
Disease Namemonoclonal gammopathy of uncertain significance
Organismhuman
UMLS CUIC0278494
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1152350, GSM1152351, GSM1152352, GSM1152353, GSM1152354
Perturbed SamplesGSM1152289, GSM1152290, GSM1152291, GSM1152292, GSM1152293, GSM1152294, GSM1152295, GSM1152296, GSM1152297, GSM1152298, GSM1152299, GSM1152300, GSM1152301, GSM1152302, GSM1152303, GSM1152304, GSM1152305, GSM1152306, GSM1152307, GSM1152308
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE47552
Gene Expression Omnibus
Monoclonal gammopathies: bone marrow plasma cells
21
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