Interaction network and enrichment analysis of genes downregulated in bipolar disorder
Canned Analysis
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General Information
AccessionDCA00033883
TitleInteraction network and enrichment analysis of genes downregulated in bipolar disorder
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by bipolar disorder and healthy control cells in the brain tissue (dorsolateral prefrontal cortex and orbitofrontal cortex) cell type.
Analysis URLhttp://genemania.org/#/search/human/PTGDS|NPIPA1|PKD1P1|TUBB2A|TUBA1C|RTN1|RPL34|ENC1|ACTB|STMN2|MORF4L1|OPHN1|RPL37|RPS29|GPM6A|NPY|GRIA2|RPS27|PRKACB|NPTN|HSP90AB1|DYNLL1|TMSB4XP8|RPL39|PEA15
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:573
Cell Typebrain tissue (dorsolateral prefrontal cortex and orbitofrontal cortex)
DO IDDOID:3312
Disease Namebipolar disorder
Organismhuman
UMLS CUIC0236780
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM123253, GSM123254, GSM123255, GSM123256, GSM123257, GSM123258, GSM123259, GSM123260, GSM123261, GSM123262, GSM123263
Perturbed SamplesGSM123182, GSM123183, GSM123184, GSM123185, GSM123186, GSM123187, GSM123188, GSM123189, GSM123190, GSM123191, GSM123192, GSM123193, GSM123194, GSM123195, GSM123196, GSM123197, GSM123198, GSM123199, GSM123200, GSM123201, GSM123202, GSM123203, GSM123204, GS
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5392
Gene Expression Omnibus
Expression profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls
7
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