Interaction network and enrichment analysis of genes upregulated in skin squamous cell carcinoma
Canned Analysis
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General Information
AccessionDCA00034032
TitleInteraction network and enrichment analysis of genes upregulated in skin squamous cell carcinoma
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by skin squamous cell carcinoma and healthy control cells in the Skin from SCCs and Normal human epidermis cell type.
Analysis URLhttp://genemania.org/#/search/human/DEFB4A|S100A7|KRT6B|S100A2|S100A9|KRT6A|SERPINB4|PI3|FABP5|SERPINB3|CYAT1|SPRR2B|KRT16|ANXA1|CSTB|SPRR1B|CSTA|PABPC1|SPRR1A|SLPI|KRT6C|ODC1|LDHA|SFN|SLC38A2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:657
Cell TypeSkin from SCCs and Normal human epidermis
DO IDDOID:3151
Disease Nameskin squamous cell carcinoma
Organismhuman
UMLS CUIC0553723
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1098446, GSM1098447, GSM1098448
Perturbed SamplesGSM1098449, GSM1098450, GSM1098451, GSM1098452, GSM1098453, GSM1098454, GSM1098455, GSM1098456, GSM1098457, GSM1098458
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE45164
Gene Expression Omnibus
Transcription profiling of human skin squamous cell carcinoma (SCC)
7
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