Interaction network and enrichment analysis of genes downregulated in esophagus squamous cell carcinoma
Canned Analysis
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General Information
AccessionDCA00034033
TitleInteraction network and enrichment analysis of genes downregulated in esophagus squamous cell carcinoma
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by esophagus squamous cell carcinoma and healthy control cells in the KYSE human esophageal squamous cell carcinoma cell line and Normal esophageal tissue cell type.
Analysis URLhttp://genemania.org/#/search/human/TUBA1A|CTHRC1|COL6A3|TGFBI|TIMP1|RND3|GREM1|CTGF|WBP5|TFPI2|CTSK|GNG11|LUM|ANXA5|DPYSL2|COL1A2|LGALS1|MT2A|SPARC|IGFBP3|COL5A2|LAMB1|TMEM47|MAGED1|KGFLP2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:658
Cell TypeKYSE human esophageal squamous cell carcinoma cell line and Normal esophageal tissue
DO IDDOID:3748
Disease Nameesophagus squamous cell carcinoma
Organismhuman
UMLS CUIC0279626
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1560964, GSM1560965, GSM1560966
Perturbed SamplesGSM1560941, GSM1560942, GSM1560943, GSM1560944, GSM1560945, GSM1560946, GSM1560947, GSM1560948, GSM1560949
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE63941
Gene Expression Omnibus
Expression data from cultured human esophageal squamous cell carcinoma cell lines and cultured human fibroblasts.
7
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