Interaction network and enrichment analysis of genes upregulated in Emery-Dreifuss muscular dystrophy
Canned Analysis
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General Information
AccessionDCA00034068
TitleInteraction network and enrichment analysis of genes upregulated in Emery-Dreifuss muscular dystrophy
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Emery-Dreifuss muscular dystrophy and healthy control cells in the whole heart cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Myl2|Gm4076|Uqcrb|Atp5g3|LOC100048117|Tnni3|Myl3|Hbb-bs|Kxd1|Chchd2|Cox6b1|Atp5j|Rpl17-ps9|Cox4i1|Atp5b|Rps29|Atp5k|Lpl|Ndufa13|Ldhb|Cox7a2|Rps2-ps6|Rps3a2|Actc1|Rps23
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDdz:675
Cell Typewhole heart
DO IDDOID:11726
Disease NameEmery-Dreifuss muscular dystrophy
Organismmouse
UMLS CUIC0410189
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM147451, GSM147452, GSM147459, GSM147460, GSM147461, GSM147462, GSM147463, GSM147465
Perturbed SamplesGSM147466, GSM147467, GSM147468, GSM147469, GSM147481, GSM147493
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6399
Gene Expression Omnibus
X-linked Emery-Dreifuss muscular dystrophy model and cardiomyopathy
12
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