Interaction network and enrichment analysis of genes downregulated in amyotrophic lateral sclerosis
Canned Analysis
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General Information
AccessionDCA00034099
TitleInteraction network and enrichment analysis of genes downregulated in amyotrophic lateral sclerosis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by amyotrophic lateral sclerosis and healthy control cells in the ocular motor neurons, 10 weeks old cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ttr|Mt3|Rtn1|Nsf|Tmcc2|Prl|Rpl17-ps9|Csde1|Zic1|Clstn1|Vamp2|Calb2|Gh|Slc22a17|Nudt3|Trim32|Dnm1|Mapk8ip1|Anxa5|Pcp4|Rab3a|Cap1|Ncdn|Clstn3|Cbx4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDdz:685
Cell Typeocular motor neurons, 10 weeks old
DO IDDOID:332
Disease Nameamyotrophic lateral sclerosis
Organismmouse
UMLS CUIC0002736
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM75472, GSM75479, GSM75484
Perturbed SamplesGSM75488, GSM75489, GSM75490
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3343
Gene Expression Omnibus
SOD1-G93A transgenic model of amyotrophic lateral sclerosis: oculomotor nucleus
24
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