Interaction network and enrichment analysis of genes downregulated in epidermolysis bullosa simplex
Canned Analysis
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General Information
AccessionDCA00034157
TitleInteraction network and enrichment analysis of genes downregulated in epidermolysis bullosa simplex
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by epidermolysis bullosa simplex and healthy control cells in the Epidermal punch biopsies cell type.
Analysis URLhttp://genemania.org/#/search/human/MIR675|HBA2|ACTA2|APOD|LOR|CFD|CYBRD1|HBB|IGFBP5|RNASE1|LCE2C|PPAP2B|LHFP|DCN|LCE2B|MFAP4|MYH11|ACTG2|KPRP|PM20D1|TIMP2|SYNPO2|SFRP2|LCE1C|CSRP1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:711
Cell TypeEpidermal punch biopsies
DO IDDOID:4644
Disease Nameepidermolysis bullosa simplex
Organismhuman
UMLS CUIC0079298
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM700422, GSM700423, GSM700424, GSM700425, GSM700426, GSM700427
Perturbed SamplesGSM700428, GSM700429, GSM700430, GSM700431, GSM700432, GSM700433
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE28315
Gene Expression Omnibus
Epidermolysis Bullosa Simplex: epidermis
7
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