Interaction network and enrichment analysis of genes upregulated in asthma
Canned Analysis
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General Information
AccessionDCA00034164
TitleInteraction network and enrichment analysis of genes upregulated in asthma
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by asthma and healthy control cells in the Circulating CD8+ T-cells (severe asthma) cell type.
Analysis URLhttp://genemania.org/#/search/human/DEFA1B|S100A9|LTF|RPL32|RPS4X|CAMP|B2M|LCN2|PLP2|SLC38A2|DEFA4|RPS2|HSPA8|ND2|COX1|NPIPB5|RPL19|TXNIP|FAM101B|CEACAM8|CMC1|RPLP0P6|RNASE2|S100A12|C12orf57
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:714
Cell TypeCirculating CD8+ T-cells (severe asthma)
DO IDDOID:2841
Disease Nameasthma
Organismhuman
UMLS CUIC0004096
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM788331, GSM788332, GSM788333, GSM788334, GSM788335, GSM788336, GSM788337, GSM788338
Perturbed SamplesGSM788323, GSM788324, GSM788325, GSM788326, GSM788327, GSM788328, GSM788329, GSM788330
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE31773
Gene Expression Omnibus
Severe asthma: circulating CD4+ and CD8+ T-cells
33
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