Interaction network and enrichment analysis of genes upregulated in hepatitis C virus related hepatocellular carcinoma
Canned Analysis
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General Information
AccessionDCA00034238
TitleInteraction network and enrichment analysis of genes upregulated in hepatitis C virus related hepatocellular carcinoma
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by hepatitis C virus related hepatocellular carcinoma and healthy control cells in the Peripheral blood mononuclear cells cell type.
Analysis URLhttp://genemania.org/#/search/human/HBA2|DCAF6|ND2|ACTB|HLA-A|COX1|DEFA1B|MSN|SH3KBP1|HLA-B|HIST1H2AC|PSAP|HLA-C|COX2|LAPTM5|HLA-E|SELL|PPBP|RPS26|CORO1A|HCLS1|ACTG1|TMSB10|TRBC1|IFITM2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:736
Cell TypePeripheral blood mononuclear cells
Disease Namehepatitis C virus related hepatocellular carcinoma
Organismhuman
UMLS CUIC1333978
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1403331, GSM1403332, GSM1403333, GSM1403334, GSM1403335
Perturbed SamplesGSM1403319, GSM1403320, GSM1403321, GSM1403322, GSM1403323, GSM1403324, GSM1403325, GSM1403326, GSM1403327, GSM1403328, GSM1403329, GSM1403330
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE58208
Gene Expression Omnibus
Gene expression profiling of PBMC from normal individuals, chronic hepatitis B carriers and hepatocellular carcinoma patients
14
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