Interaction network and enrichment analysis of genes downregulated in multiple sclerosis
Canned Analysis
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General Information
AccessionDCA00034241
TitleInteraction network and enrichment analysis of genes downregulated in multiple sclerosis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by multiple sclerosis and healthy control cells in the brain lesion (MS after inflammation - late stage) cell type.
Analysis URLhttp://genemania.org/#/search/human/TTR|SYS1-DBNDD2|CARNS1|B2M|ENPP2|TP53INP2|HSPA2|S100B|CNP|CRYAB|RNASE1|MARCKSL1|PLLP|PAQR6|PLP1|APLP1|OLIG1|PSAP|APOD|PTGDS|MAL|CD9|PLEKHH1|CNDP1|RHOA
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:738
Cell Typebrain lesion (MS after inflammation - late stage)
DO IDDOID:2377
Disease Namemultiple sclerosis
Organismhuman
UMLS CUIC0026769
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM931812, GSM931813
Perturbed SamplesGSM931817, GSM931818
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE38010
Gene Expression Omnibus
Multiple sclerosis: brain lesions
14
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