Interaction network and enrichment analysis of genes downregulated in Psoriasis vulgaris
Canned Analysis
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General Information
AccessionDCA00034271
TitleInteraction network and enrichment analysis of genes downregulated in Psoriasis vulgaris
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Psoriasis vulgaris and healthy control cells in the Skin tissue cell type.
Analysis URLhttp://genemania.org/#/search/human/DCD|DCAF6|PIP|TMSB4XP8|KRT85|SH3KBP1|SLC38A2|KRT31|COX2|DDIT4|NFKBIA|ADM|ND2|SCGB2A2|CEBPB|TXNIP|UBC|ZFP36|KRT77|FOS|KRT25|IER2|KRT33A|NDRG1|FOXQ1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:93
Cell TypeSkin tissue
Disease NamePsoriasis vulgaris
Organismhuman
UMLS CUIC0263361
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM372286, GSM372287, GSM372288, GSM372289, GSM372290, GSM372291, GSM372292, GSM372293, GSM372294, GSM372295, GSM372296, GSM372297, GSM372298, GSM372299, GSM372300, GSM372301, GSM372302, GSM372303, GSM372304, GSM372305, GSM372306
Perturbed SamplesGSM372308, GSM372310, GSM372312, GSM372314, GSM372316, GSM372318, GSM372320, GSM372322, GSM372324, GSM372325, GSM372327, GSM372329, GSM372331, GSM372333, GSM372334, GSM372336, GSM372338, GSM372340, GSM372342, GSM372344, GSM372346, GSM372348, GSM372350, GS
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE14905
Gene Expression Omnibus
Psoriasis
14
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