Interaction network and enrichment analysis of genes downregulated in gastrointestinal stromal tumor
Canned Analysis
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General Information
AccessionDCA00034275
TitleInteraction network and enrichment analysis of genes downregulated in gastrointestinal stromal tumor
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by gastrointestinal stromal tumor and healthy control cells in the Gastric Tissue cell type.
Analysis URLhttp://genemania.org/#/search/human/MYOC|ACTRT2|CXCL8|EDN3|MMP1|FAM150B|FIBIN|BCHE|PID1|LINC01096|LOC101929497|DCN|FNDC1|HAND1|TRIM64|ACTA2|CA2|CDK5RAP1|FAM89B|FABP5|IL33|LOC100289094|DNM3OS|G0S2|CDH11
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:76
Cell TypeGastric Tissue
DO IDDOID:9253
Disease Namegastrointestinal stromal tumor
Organismhuman
UMLS CUIC0238198
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM400206, GSM400208, GSM400210, GSM400212, GSM400214, GSM400220, GSM400226, GSM400227, GSM400228, GSM400230, GSM400232, GSM400240, GSM400241, GSM400242, GSM400246, GSM400251, GSM400252, GSM400258
Perturbed SamplesGSM400216, GSM400218, GSM400222, GSM400224, GSM400234, GSM400236, GSM400238, GSM400245, GSM400248, GSM400255
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE15966
Gene Expression Omnibus
Gene expression signature predictive of rapid response to imatinib mesylate in Gastrointestinal Stromal Tumor (GIST)
7
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