Interaction network and enrichment analysis of genes downregulated in cardiomyopathy
Canned Analysis
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General Information
AccessionDCA00034295
TitleInteraction network and enrichment analysis of genes downregulated in cardiomyopathy
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by cardiomyopathy and healthy control cells in the Peripheral blood mononuclear cells (non-ischemic cardiomyopathy) cell type.
Analysis URLhttp://genemania.org/#/search/human/DEFA1B|PPBP|HBB|NFKBIA|HBA2|ACTB|GNLY|S100A9|PF4|RPL9|RPL23A|RPS25|B2M|RPLP1|PRF1|YPEL5|HLA-DRB5|H3F3AP4|RPL32|NRGN|TNFAIP3|LTF|GPX1|IFITM3|HLA-A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:780
Cell TypePeripheral blood mononuclear cells (non-ischemic cardiomyopathy)
DO IDDOID:0050700
Disease Namecardiomyopathy
Organismhuman
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM231003, GSM231004, GSM231005
Perturbed SamplesGSM231006, GSM231007, GSM231008, GSM231009
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE9128
Gene Expression Omnibus
Heart failure: peripheral blood mononuclear cells
14
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