Interaction network and enrichment analysis of genes downregulated in acute myeloid leukemia
Canned Analysis
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General Information
AccessionDCA00034301
TitleInteraction network and enrichment analysis of genes downregulated in acute myeloid leukemia
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by acute myeloid leukemia and healthy control cells in the Peripheral blood cell type.
Analysis URLhttp://genemania.org/#/search/human/IFITM2|MNDA|RGS2|HBB|S100A9|HLA-B|CEBPB|TYROBP|FCGR3B|H3F3AP4|DEFA1B|PPBP|SORL1|S100P|HLA-C|HBA2|HCK|IFITM3|ITM2B|NAMPT|IFITM1|CXCR2|VNN2|PF4|G0S2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:783
Cell TypePeripheral blood
DO IDDOID:9119
Disease Nameacute myeloid leukemia
Organismhuman
UMLS CUIC0023467
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM240430, GSM240431, GSM240432, GSM240433, GSM240494, GSM240495, GSM240496, GSM240497, GSM240498, GSM240499
Perturbed SamplesGSM239345, GSM239346, GSM239348, GSM239363, GSM239460, GSM239485, GSM239488, GSM239490, GSM239491, GSM239493, GSM239494, GSM239495, GSM239496, GSM239498, GSM239516, GSM239580, GSM240405, GSM240406, GSM240429
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE9476
Gene Expression Omnibus
Acute myeloid leukemia
14
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