Interaction network and enrichment analysis of genes downregulated in Kidney disorder associated with type 2 diabetes mellitus
Canned Analysis
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General Information
AccessionDCA00034323
TitleInteraction network and enrichment analysis of genes downregulated in Kidney disorder associated with type 2 diabetes mellitus
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Kidney disorder associated with type 2 diabetes mellitus and healthy control cells in the Mesangial cell cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Creld2|Manf|Calr|Hsp90b1|Sdf2l1|2410006H16Rik|Hspa5|Herpud1|Rpn1|Dnajb11|Pdia4|Slc35b1|P4hb|1500012F01Rik|Serp1|Cyb5r1|Ppp1r15a|Npm1|Gsto1|Slc3a2|Nupr1|Rpl4|Ppib|Trib3|Tbcb
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:8
Cell TypeMesangial cell
Disease NameKidney disorder associated with type 2 diabetes mellitus
Organismmouse
UMLS CUIC1720457
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM48385, GSM48393
Perturbed SamplesGSM48387, GSM48388, GSM48389, GSM48390
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2557
Gene Expression Omnibus
Glucosamine and high glucose effect on renal mesangial cells
7
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