Interaction network and enrichment analysis of genes downregulated following L-arginine treatment
Canned Analysis
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General Information
AccessionDCA00034327
TitleInteraction network and enrichment analysis of genes downregulated following L-arginine treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between L-arginine treated cells and untreated control cells in the Colon (DSS - induced colitis) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Sycn|Klk1b5|Car4|Adh1|S100g|Ccl6|Clca3|Tgm3|Acta2|Cd24a|Hpgd|Aoc1|Rpl39|Prf1|Gstp1|Rn7sk|Gm10925|Nxpe2|Naaladl1|Myl9|Ugdh|Car2|Hmgcs2|Ugt2b34|Uqcrb
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3214
Cell TypeColon (DSS - induced colitis)
Drug NameL-arginine
Organismmouse
PubChem CID6322
SMILES IDC(CC(C(=O)O)N)CN=C(N)N
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM856810, GSM856811, GSM856812
Perturbed SamplesGSM856816, GSM856817, GSM856818
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE34874
Gene Expression Omnibus
DSS-induced colitis model response to L-arginine supplementation
14
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