Interaction network and enrichment analysis of genes upregulated in precursor B lymphoblastic lymphoma/leukemia
Canned Analysis
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General Information
AccessionDCA00034332
TitleInteraction network and enrichment analysis of genes upregulated in precursor B lymphoblastic lymphoma/leukemia
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by precursor B lymphoblastic lymphoma/leukemia and healthy control cells in the AT2 E/R positive BCP ALL cell line (following E/R -ETV6/RUNX1- knockdown) cell type.
Analysis URLhttp://genemania.org/#/search/human/RPS6|CYAT1|COX1|PTGES3|IGLC7|HLA-DRB5|HLA-DRA|HLA-DRB4|ATF4|RRM2|SLC7A5|IER2|HLA-DRB1|AARS|H2AFZ|VPREB3|DDIT4|HLA-A|FTH1P5|HERPUD1|LAPTM5|HLA-B|IARS|CD79A|ACTG1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:803
Cell TypeAT2 E/R positive BCP ALL cell line (following E/R -ETV6/RUNX1- knockdown)
DO IDDOID:7061
Disease Nameprecursor B lymphoblastic lymphoma/leukemia
Organismhuman
UMLS CUIC0862030
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM734473, GSM734475
Perturbed SamplesGSM734474, GSM734476
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE29639
Gene Expression Omnibus
Leukemia-specific fusion gene ETV6/RUNX1 knockdown effect on ETV6/RUNX1-positive, B-cell precursor acute lymphoblastic leukemia cell lines
14
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