Interaction network and enrichment analysis of genes downregulated in RUNX1 KD
Canned Analysis
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General Information
AccessionDCA00034333
TitleInteraction network and enrichment analysis of genes downregulated in RUNX1 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between RUNX1 KD cells and control cells in the Analysis of ETV6/RUNX1 (E/R) fusion gene-positive in BCP ALL cell lines (REH) following E/R knockdown cell type.
Analysis URLhttp://genemania.org/#/search/human/TMSB10|EEF1B2|TPT1|TUBA1A|CD52|EEF1A1P9|PROM1|LINC00341|RPS8|FAM107B|SERINC5|KIAA0226L|SETP4|GNG11|EIF3E|SLC35E3|DPYSL2|RPS18|RPL39|TMEM263|RPL36A|RPL34|RPL30|SET|ID3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:1288
Cell TypeAnalysis of ETV6/RUNX1 (E/R) fusion gene-positive in BCP ALL cell lines (REH) following E/R knockdown
Gene Symbol (human)RUNX1
Gene Symbol (mouse)Runx1
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM734477, GSM734479, GSM734481
Perturbed SamplesGSM734478, GSM734480, GSM734482
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE29639
Gene Expression Omnibus
Leukemia-specific fusion gene ETV6/RUNX1 knockdown effect on ETV6/RUNX1-positive, B-cell precursor acute lymphoblastic leukemia cell lines
14
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