Interaction network and enrichment analysis of genes upregulated in cystic fibrosis
Canned Analysis
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General Information
AccessionDCA00034396
TitleInteraction network and enrichment analysis of genes upregulated in cystic fibrosis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by cystic fibrosis and healthy control cells in the Rectal mucosal epithelia (CFTR D508 Mutation) cell type.
Analysis URLhttp://genemania.org/#/search/human/ZG16|PLA2G2A|S100P|ACTB|CYAT1|IER3|PIGR|FCGBP|SPINK4|LCN2|IGHV4-31|TFF3|LGALS4|S100A6|CLCA1|FABP1|MUC2|CFL1|TMSB10|OLFM4|PFN1|CEACAM6|ZFP36|HSPA1B|HSPA1A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:833
Cell TypeRectal mucosal epithelia (CFTR D508 Mutation)
DO IDDOID:1485
Disease Namecystic fibrosis
Organismhuman
UMLS CUIC0010674
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM389668, GSM389669, GSM389670, GSM389671, GSM389672, GSM389673, GSM389674, GSM389675, GSM389676, GSM389677, GSM389678, GSM389679, GSM389680
Perturbed SamplesGSM389652, GSM389653, GSM389654, GSM389655, GSM389656, GSM389657, GSM389658, GSM389659, GSM389660, GSM389661, GSM389662, GSM389663, GSM389664, GSM389665, GSM389666, GSM389667
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE15568
Gene Expression Omnibus
Cystic fibrosis: rectal epithelia
12
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