Interaction network and enrichment analysis of genes upregulated in idiopathic pulmonary fibrosis
Canned Analysis
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General Information
AccessionDCA00034434
TitleInteraction network and enrichment analysis of genes upregulated in idiopathic pulmonary fibrosis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by idiopathic pulmonary fibrosis and healthy control cells in the Lung fibroblasts (Slow progressing fibrosis) cell type.
Analysis URLhttp://genemania.org/#/search/human/GREM1|CTGF|SERPINB2|TUBA1B|CTHRC1|TIMP1|SRGN|S100A4|TFPI2|SPARC|HERPUD1|DACT1|FRMD6|CXCL8|PTGS2|STC1|TNFRSF11B|SNHG5|CEBPB|DKK1|SFRP1|IGFBP3|IL6|CCL2|CDH11
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:851
Cell TypeLung fibroblasts (Slow progressing fibrosis)
DO IDDOID:0050156
Disease Nameidiopathic pulmonary fibrosis
Organismhuman
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1089616, GSM1089617, GSM1089618, GSM1089620
Perturbed SamplesGSM1089615, GSM1089621, GSM1089624, GSM1089625, GSM1089626, GSM1089627
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE44723
Gene Expression Omnibus
Idiopathic pulmonary fibrosis: cultured lung fibroblasts
14
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