Interaction network and enrichment analysis of genes upregulated in adrenoleukodystrophy
Canned Analysis
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General Information
AccessionDCA00034458
TitleInteraction network and enrichment analysis of genes upregulated in adrenoleukodystrophy
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by adrenoleukodystrophy and healthy control cells in the Induced pluripotent stem cells -iPSC- (derived from childhood cerebral adrenoleukodystrophy patient dermal fibroblasts) and healthy fibroblasts cell type.
Analysis URLhttp://genemania.org/#/search/human/RPS4Y1|ID1|SNURF|RPS26|SLC2A3|TFRC|IFITM2|MIF|HSPA5|CFL1|IER2|PABPC1|SLC2A14|TUBB2A|SPP1|CTGF|TDGF1P3|FTL|CYR61|SLC38A2|GAPDH|RLIM|ADM|PRDX6|NANOG
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:865
Cell TypeInduced pluripotent stem cells -iPSC- (derived from childhood cerebral adrenoleukodystrophy patient dermal fibroblasts) and healthy fibroblasts
DO IDDOID:10588
Disease Nameadrenoleukodystrophy
Organismhuman
UMLS CUIC0162309
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM847093, GSM847094, GSM847095, GSM847096, GSM847097, GSM847098, GSM847099, GSM847100
Perturbed SamplesGSM847101, GSM847102, GSM847103, GSM847104, GSM847105
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE34309
Gene Expression Omnibus
Childhood cerebral adrenoleukodystrophy patient-specific iPSC model
14
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