Interaction network and enrichment analysis of genes downregulated in idiopathic pulmonary fibrosis
Canned Analysis
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General Information
AccessionDCA00034465
TitleInteraction network and enrichment analysis of genes downregulated in idiopathic pulmonary fibrosis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by idiopathic pulmonary fibrosis and healthy control cells in the Lung - UPPER LOBE - ADVANCED idiopathic pulmonary fibrosis - Female cell type.
Analysis URLhttp://genemania.org/#/search/human/SPARCL1|RPL9|SCGB3A2|RPLP0|ID1|C4BPA|S100A9|IL1R2|HNRNPA1P10|GAPDH|EEF1A1P9|RPSA|GPX3|RPLP0P6|TIMP1|S100A12|RPL23A|SERPINA3|RPS29|RPS5|ADM|TXNIP|RPS7|FKBP5|MFSD1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:869
Cell TypeLung - UPPER LOBE - ADVANCED idiopathic pulmonary fibrosis - Female
DO IDDOID:0050156
Disease Nameidiopathic pulmonary fibrosis
Organismhuman
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM595407, GSM595411, GSM595414, GSM595416, GSM595417, GSM595419
Perturbed SamplesGSM595435, GSM595443
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24206
Gene Expression Omnibus
Early and advanced idiopathic pulmonary fibrosis: whole lung
42
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