Interaction network and enrichment analysis of genes upregulated in relapsing-remitting multiple sclerosis
Canned Analysis
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General Information
AccessionDCA00034488
TitleInteraction network and enrichment analysis of genes upregulated in relapsing-remitting multiple sclerosis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by relapsing-remitting multiple sclerosis and healthy control cells in the CD4+ T cells Lymphocytes (sorted from PBMCs from monozygotic twin pairs discordant for RRMS) cell type.
Analysis URLhttp://genemania.org/#/search/human/RPS3A|RPS12|RPL24|JUNB|TUBA1A|RPS17|RPL41|RPL4|FAU|RPL8|CCL4|TMSB4XP8|EEF1B2|TUBA1C|SNRPD2|RPS14P3|CD3D|TIMP1|TNFAIP3|RPL12|KLF10|RPL32|RPL29|COMMD6|PPBP
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:879
Cell TypeCD4+ T cells Lymphocytes (sorted from PBMCs from monozygotic twin pairs discordant for RRMS)
DO IDDOID:2378
Disease Namerelapsing-remitting multiple sclerosis
Organismhuman
UMLS CUIC0751967
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM413790, GSM413792, GSM413795, GSM413796
Perturbed SamplesGSM413791, GSM413793, GSM413794, GSM413797
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE16461
Gene Expression Omnibus
Identical twins discordant for Multiple sclerosis: CD4+ and CD8+ T cells
7
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