Interaction network and enrichment analysis of genes downregulated following Pioglitazone treatment
Canned Analysis
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General Information
AccessionDCA00034493
TitleInteraction network and enrichment analysis of genes downregulated following Pioglitazone treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Pioglitazone treated cells and untreated control cells.
Analysis URLhttp://genemania.org/#/search/human/ATP6|ENO3|MYH1|OAZ1|TNNI1|GAPDHP62|RBM38|RPLP0P6|FHL1|MYH4|COX3|ADCK3|ACTA1|UBC|MYBPC1|CAPN3|ASB2|ATF4|TMEM70|HSPA8|MYH2|SNHG5|CASQ1|NDRG2|G0S2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2796
Drug NamePioglitazone
DrugBank IDDB01132
Organismhuman
PubChem CID4829
SMILES IDCCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM201542, GSM201543, GSM201544, GSM201545, GSM201829, GSM201830, GSM201831, GSM201832, GSM201833, GSM201834
Perturbed SamplesGSM201835, GSM201836, GSM201837, GSM201838, GSM201839, GSM201840, GSM201841, GSM201842, GSM201843, GSM201844
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8157
Gene Expression Omnibus
Obese women with polycystic ovary syndrome and obese, healthy women: skeletal muscle
14
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