Interaction network and enrichment analysis of genes downregulated in endometriosis
Canned Analysis
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General Information
AccessionDCA00034497
TitleInteraction network and enrichment analysis of genes downregulated in endometriosis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by endometriosis and healthy control cells in the Endometrial tissue (Endometrioma tissue and eutopic endometrium controls) cell type.
Analysis URLhttp://genemania.org/#/search/human/SCGB2A1|ALDH1A2|H19|TMEM158|MSX1|RNASET2|HSPB1|CD81|CD248|TFF3|PGRMC1|CNDP2|ESR1|SCGB3A1|SLPI|CRIP1|HIST1H4C|MYL6|TXN|BPIFB1|MMP7|PPA1|DKK1|SCGB1D2|CSRP1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:883
Cell TypeEndometrial tissue (Endometrioma tissue and eutopic endometrium controls)
DO IDDOID:289
Disease Nameendometriosis
Organismhuman
UMLS CUIC0014175
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM572752, GSM572753, GSM572754, GSM572755, GSM572756, GSM572757, GSM572761, GSM572762, GSM572764
Perturbed SamplesGSM572747, GSM572748, GSM572749, GSM572750, GSM572751, GSM572758, GSM572759, GSM572760, GSM572763, GSM572765
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE23339
Gene Expression Omnibus
Endometriosis: endometrial tissue
7
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