Interaction network and enrichment analysis of genes downregulated in schizophrenia
Canned Analysis
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General Information
AccessionDCA00034505
TitleInteraction network and enrichment analysis of genes downregulated in schizophrenia
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by schizophrenia and healthy control cells in the Induced pluripotent stem cell-derived neurons - Female cell type.
Analysis URLhttp://genemania.org/#/search/human/GFAP|FBXO32|ITGB8|NAMPT|ACTA2|RN7SK|SPARCL1|ADAM9|SALL1|SCARNA17|CD99|WLS|TUBA1A|GPT2|ASAH1|BEX1|LDHB|SPTAN1|SPON1|ENO1|FHL1|C1orf61|CPNE4|APP|SOX2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:892
Cell TypeInduced pluripotent stem cell-derived neurons - Female
DO IDDOID:5419
Disease Nameschizophrenia
Organismhuman
UMLS CUIC0220702
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM630788, GSM630789, GSM630790, GSM630791, GSM630792, GSM630793, GSM630794, GSM630795, GSM630796
Perturbed SamplesGSM630800, GSM630801, GSM630802
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE25673
Gene Expression Omnibus
Induced pluripotent stem cell-derived neurons from schizophrenia patients
14
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