Interaction network and enrichment analysis of genes downregulated in type 1 diabetes mellitus
Canned Analysis
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General Information
AccessionDCA00034511
TitleInteraction network and enrichment analysis of genes downregulated in type 1 diabetes mellitus
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by type 1 diabetes mellitus and healthy control cells in the T lymphocyte cell type.
Analysis URLhttp://genemania.org/#/search/human/COX1|RPS4Y1|COX2|EEF1A1P9|DCAF6|RPL30|SLC25A3|HLA-A|PABPC3|RPL6|EEF1G|ACTG1|RLIM|EIF3E|NACAP1|TIPARP|EIF3H|UBC|RPL3|HLA-DRB4|KLRB1|HLA-C|ATP5B|AIM1|RPS8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:9
Cell TypeT lymphocyte
DO IDDOID:9744
Disease Nametype 1 diabetes mellitus
Organismhuman
UMLS CUIC0011854
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM266963, GSM266964, GSM266965, GSM266966, GSM266967, GSM266968, GSM266969, GSM266970, GSM266971, GSM266972, GSM266973, GSM266974, GSM266975, GSM266976, GSM266977
Perturbed SamplesGSM266978, GSM266979, GSM266980, GSM266981, GSM266982, GSM266983, GSM266984, GSM266985, GSM266986, GSM266987, GSM266988, GSM266989
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE10586
Gene Expression Omnibus
Expression data from recent-onset T1D patients and controls
7
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