Interaction network and enrichment analysis of genes upregulated in osteoarthritis
Canned Analysis
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General Information
AccessionDCA00034576
TitleInteraction network and enrichment analysis of genes upregulated in osteoarthritis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by osteoarthritis and healthy control cells in the Articular CONDROCYTES from osteoarthritic knees of Sprague-Dawley males and Normal Contralateral control cell type.
Analysis URLhttp://genemania.org/#/search/rat/Tnn|Crabp2|Ccl2|Col5a3|Tagln|C1qtnf3|Fndc1|LOC680687|F3|Prss46|Rgs1|Gtse1|Ahsp|Rrad|Ccl7|Csrp2|Inhba|Plaur|LOC290595|Plscr2|Mknk2|RGD1561916|Aspn|Gadd45g|Nnmt
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:944
Cell TypeArticular CONDROCYTES from osteoarthritic knees of Sprague-Dawley males and Normal Contralateral control
DO IDDOID:8398
Disease Nameosteoarthritis
Organismrat
UMLS CUIC0157946
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM199974, GSM200589, GSM200590, GSM200591, GSM200592
Perturbed SamplesGSM199973, GSM200585, GSM200586, GSM200587, GSM200588
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE8077
Gene Expression Omnibus
Knee osteoarthritis model: chondrocytes
14
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