Interaction network and enrichment analysis of genes upregulated in Intestinal polyposis
Canned Analysis
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General Information
AccessionDCA00034594
TitleInteraction network and enrichment analysis of genes upregulated in Intestinal polyposis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by Intestinal polyposis and healthy control cells in the Intestinal POLYPS model (generated by the deletion of the phosphatase PTEN gene from the intestine) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Defa24|Spink4|Rps3a2|Gm15315|Rpl26|Zfp526|Rps27a|Rps6-ps4|Krt19|Dmbt1|Rplp2|Rps29|Defa-rs1|Defa22|Rpl3|Rpl31|Rpl27a|Rpl13|Rpl17-ps9|Ino80|Rps16-ps2|Rps2|Rplp0|Rplp1|Tmsb4x
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:952
Cell TypeIntestinal POLYPS model (generated by the deletion of the phosphatase PTEN gene from the intestine)
Disease NameIntestinal polyposis
Organismmouse
UMLS CUIC1257915
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM140792, GSM140816
Perturbed SamplesGSM140813, GSM140817, GSM140818
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE6078
Gene Expression Omnibus
Intestinal polyposis model
12
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