Interaction network and enrichment analysis of genes downregulated in progeria
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00034615
TitleInteraction network and enrichment analysis of genes downregulated in progeria
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by progeria and healthy control cells in the liver cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Car3|Mup19|Fabp1|Serpina6|Ces3a|Cat|Fads2|Mup3|Cyp2f2|Cyp1a2|Hsd17b6|Cml2|Hmgcs2|Cyp2c44|Gamt|Dhcr24|Pklr|Fasn|Cyp2b9|Cyp2d37-ps|Mug2|Mup20|Cideb|Akr1c6|Plin2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDdz:984
Cell Typeliver
DO IDDOID:3911
Disease Nameprogeria
Organismmouse
UMLS CUIC0033300
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM808406, GSM808407, GSM808408
Perturbed SamplesGSM808403, GSM808404, GSM808405
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE32609
Gene Expression Omnibus
Lmna G609G knock-in model of Hutchinson-Gilford Progeria Syndrome: liver
12
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.