Interaction network and enrichment analysis of genes downregulated following Tretinoin treatment
Canned Analysis
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General Information
AccessionDCA00034643
TitleInteraction network and enrichment analysis of genes downregulated following Tretinoin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Tretinoin treated cells and untreated control cells in the F9 teratocarcinoma cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ptgs2|Nkx2-2|Tox3|Cdh9|Fgfbp1|St6gal2|Otx2|Pou4f2|Gm4340|Wisp1|Kctd12b|Sema3c|Slco4c1|D2Ertd173e|Fst|Insm1|Penk|Ascl2|LOC100504708|Neurog3|Abhd15|Rnf182|Cdhr1|Slc27a2|Scn3a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsaulc07
CREEDS IDdrug:2460
Cell TypeF9 teratocarcinoma cells
Drug NameTretinoin
DrugBank IDDB00755
Organismmouse
PubChem CID444795
SMILES IDCC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM775291, GSM775295, GSM775299
Perturbed SamplesGSM775292, GSM775296, GSM775300
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE31280
Gene Expression Omnibus
All-trans retinoic acid effect on retinoic acid receptor -deficient F9 teratocarcinoma cells
21
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