Interaction network and enrichment analysis of genes downregulated following Ribavirin treatment
Canned Analysis
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General Information
AccessionDCA00034689
TitleInteraction network and enrichment analysis of genes downregulated following Ribavirin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Ribavirin treated cells and untreated control cells in the uninfected hepatoma Huh7.5.1 cells cell type.
Analysis URLhttp://genemania.org/#/search/human/HIST1H2BK|ANP32B|H2BFS|TUBB|TUBA1C|SH3KBP1|ATF4|EDF1|NPM1|PHGDH|H2AFZ|NME1|HIST2H2AA4|PPIB|PSAT1|CDC20|UBE2S|FADS1|CEBPA|EIF3CL|PABPC3|HNRNPA1P10|HSPA8|UBE2C|HIST1H1C
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortimkenny92
CREEDS IDdrug:2481
Cell Typeuninfected hepatoma Huh7.5.1 cells
Drug NameRibavirin
DrugBank IDDB00811
Organismhuman
PubChem CID37542
SMILES IDC1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM568463, GSM568464, GSM568465
Perturbed SamplesGSM568466, GSM568467, GSM568468
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE23031
Gene Expression Omnibus
Ribavirin effect on uninfected hepatoma Huh7.5.1 cells
7
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