Interaction network and enrichment analysis of genes upregulated following Doxorubicin treatment
Canned Analysis
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General Information
AccessionDCA00034702
TitleInteraction network and enrichment analysis of genes upregulated following Doxorubicin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Doxorubicin treated cells and untreated control cells in the Eµ-myc transgenic lymphoma cells deficient in Suv39h1 cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Lyz2|S100a11|Iglc3|Wfdc17|Gm4076|Psap|Mzb1|Lgmn|Saa3|Iglc2|Stfa3|Ccl9|Ftl1|Fth1|BC094435|Serpine2|Ctss|Tmed6|S100a4|Ctsz|Rps27rt|Pld4|Arhgdib|Ccng1|Grn
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortimkenny92
CREEDS IDdrug:2486
Cell TypeEµ-myc transgenic lymphoma cells deficient in Suv39h1
Drug NameDoxorubicin
DrugBank IDDB00997
Organismmouse
PubChem CID31703
SMILES IDCC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1083870, GSM1083872, GSM1083874, GSM1083876, GSM1083878
Perturbed SamplesGSM1083871, GSM1083873, GSM1083875, GSM1083877, GSM1083879
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE44355
Gene Expression Omnibus
Adriamycin in vitro effect on E-myc transgenic lymphoma cells deficient in Suv39h1
7
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