Interaction network and enrichment analysis of genes upregulated following Estradiol treatment
Canned Analysis
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General Information
AccessionDCA00034704
TitleInteraction network and enrichment analysis of genes upregulated following Estradiol treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Estradiol treated cells and untreated control cells in the Breast adenocarcinoma MCF-7 cell line cell type.
Analysis URLhttp://genemania.org/#/search/human/TFF1|TUBA1C|KPNA2|H2AFZ|RRM2|TUBB|NPY1R|HSPA8|TUBB4B|TPD52L1|HSP90AA1|GLA|SULF2|PRC1|BRIP1|TUBA1A|TMEM64|PCNA|COX6C|RAN|SFXN2|NME1|KIAA0101|CKS1B|WISP2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortimkenny92
CREEDS IDdrug:2487
Cell TypeBreast adenocarcinoma MCF-7 cell line
Drug NameEstradiol
DrugBank IDDB00783
Organismhuman
PubChem CID5757
SMILES IDCC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1141244, GSM1141245, GSM1141246
Perturbed SamplesGSM1141241, GSM1141242, GSM1141243
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE46924
Gene Expression Omnibus
Breast adenocarcinoma MCF-7 cell line response to 27-Hydroxycholesterol and estradiol
7
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